神経疾患におけるフェロトーシスの役割
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Role of ferroptosis in neurological diseases
MY Yao, T Liu, L Zhang, MJ Wang, Y Yang, J Gao - Neuroscience Letters, 2021 - Elsevier
… syndromes with associated epilepsy, which supports the continued clinical evaluation of
EPI-743 as a therapeutic agent for PCH6 and other mitochondrial diseases with associated …
EPI-743 as a therapeutic agent for PCH6 and other mitochondrial diseases with associated …
Role of ferroptosis in neurological diseases
Abstract
Ferroptosis is a newly identified form of nonapoptotic regulated cell death (RCD) characterized by iron-dependent accumulation of lipid peroxides which leads to oxidative stress and cell death. Recent studies have indicated that ferroptosis plays an essential role in the pathology of neurological diseases, such as intracerebral hemorrhage, ischemic stroke, epilepsy, neurodegenerative diseases, traumatic brain injury and brain cancer. This review focuses on the latest researches on the relationship of ferroptosis with nervous system diseases, highlighting the ferroptosis-based mechanisms, and elaborating the new perspective therapeutic targets of neurological disorders.
Abstract
Ferroptosis is a newly identified form of nonapoptotic regulated cell death (RCD) characterized by iron-dependent accumulation of lipid peroxides which leads to oxidative stress and cell death. Recent studies have indicated that ferroptosis plays an essential role in the pathology of neurological diseases, such as intracerebral hemorrhage, ischemic stroke, epilepsy, neurodegenerative diseases, traumatic brain injury and brain cancer. This review focuses on the latest researches on the relationship of ferroptosis with nervous system diseases, highlighting the ferroptosis-based mechanisms, and elaborating the new perspective therapeutic targets of neurological disorders.
- 神経疾患におけるフェロトーシスの役割
概要
フェロトーシスは、酸化ストレスと細胞死につながる過酸化脂質の鉄依存性蓄積を特徴とする、新たに同定された非アポトーシス性調節細胞死 (RCD) の形態です。 最近の研究は、フェロトーシスが脳内出血、虚血性脳卒中、てんかん、神経変性疾患、外傷性脳損傷、脳腫瘍などの神経疾患の病理学において重要な役割を果たすことを示しています。 このレビューは、フェロトーシスと神経系疾患との関係に関する最新の研究に焦点を当て、フェロトーシスに基づくメカニズムを強調し、神経障害の新しい視点の治療標的を精緻化します。
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