” [HTML] Empagliflozin activates Wnt/β-catenin to stimulate FUNDC1-dependent mitochondrial quality surveillance against type-3 cardiorenal syndrome C Cai, F Wu, B Zhuang, Q Ou, X Peng, N Shi… - Molecular …, 2022 - Elsevier … Mitochondrial …

” Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction J Miao, J Liu, J Niu, Y Zhang, W Shen, C Luo, Y Liu… - Aging cell, 2019 - Wiley Online Library … 2.7 Wnt/β-catenin/RAS axis …

” [HTML] Impaired mitochondrial ATP production downregulates Wnt signaling via ER stress induction R Costa, R Peruzzo, M Bachmann, G Dalla Monta… - Cell reports, 2019 - Elsevier … a generated zebrafish model lead to reduced Wnt signaling. …

” [HTML] Challenges of mitochondrial DNA editing in mammalian cells: focus on treatment of cardiovascular disease VA Khotina, M Bagheri Ekta, MS Baig, WK Wu… - Vessel Plus, 2022 Atherosclerosis is the major cause of occurrence and developm…

” [HTML] Total and reduced/oxidized forms of coenzyme Q10 in fibroblasts of patients with mitochondrial disease C Watanabe, H Osaka, M Watanabe, A Miyauchi… - Molecular Genetics and …, 2023 … We studied fibroblasts from 24 patients with mi…

” Role of ferroptosis in neurological diseases MY Yao, T Liu, L Zhang, MJ Wang, Y Yang, J Gao - Neuroscience Letters, 2021 - Elsevier … syndromes with associated epilepsy, which supports the continued clinical evaluation ofEPI-743 as a the…

” Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway S Wei, T Qiu, X Yao, N Wang, L Jiang, X Jia… - Journal of hazardous …, 2020 - Elsevier … of ferroptosis on pancreatic dysfunction tr…

” Mitochondrial regulation of ferroptosis B Gan - Journal of Cell Biology, 2021 - rupress.org … processes in mitochondria that actively drive ferroptosis, discuss recently discoveredmitochondria-… Therefore, this study proposes that mitoch…

” [HTML] The Nrf2 induction prevents ferroptosis in Friedreich's Ataxia P La Rosa, S Petrillo, R Turchi, F Berardinelli… - Redox biology, 2021 - Elsevier … As additional indicators of ferroptosis, we further analysed the FRDA mitochondrial…

” Ferroptosis is regulated by mitochondria in neurodegenerative diseases J Zhou, Y Jin, Y Lei, T Liu, Z Wan, H Meng… - … Diseases, 2020 - karger.com … in neurodegenerative diseases. Key Messages: … of ferroptosis, we conclude that mitochon…

Ferroptosis and cancer: mitochondria meet the “iron maiden” cell death AM Battaglia, R Chirillo, I Aversa, A Sacco, F Costanzo… - Cells, 2020 - mdpi.com … This strongly suggests that ferroptosis may act as an adaptive response to … mitocho…

" Mitochondria regulation in ferroptosis H Wang, C Liu, Y Zhao, G Gao - European journal of cell biology, 2020 - Elsevier … some oxidative stress diseases, including neurodegenerative … , the pertinence betweenmitochondria and ferroptosis …

" [HTML] OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy S Ahola, PR Mejías, S Hermans, S Chandragiri… - Cell Metabolism, 2022 - Elsevier … the heart, ultimately culminating in ferropto…

" [HTML] Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy AH Kahn-Kirby, A Amagata, CI Maeder, JJ Mei… - PLoS …, 2019 - journals.plos.org … that ferroptosis contributes to the …

" Mitochondrial disease genetics update: recent insights into the molecular diagnosis and expanding phenotype of primary mitochondrial disease EM McCormick, Z Zolkipli-Cunningham… - Current Opinion in …, 2018 - journals.lww.com … technolog…

" Therapeutic in vivo delivery of gene editing agents A Raguram, S Banskota, DR Liu - Cell, 2022 - Elsevier … Editing of mitochondrial DNA is challenged by the lack of efficient methods to deliver guideRNAs into mitochondria, precluding th…

" Mitochondrial base editor induces substantial nuclear off-target mutations Z Lei, H Meng, L Liu, H Zhao, X Rao, Y Yan, H Wu… - Nature, 2022 - nature.com … Mutations in mitochondrial DNA (mtDNA) are known to be associated with most adult-…

" Curing cytoplasmic male sterility via TALEN-mediated mitochondrial genome editing T Kazama, M Okuno, Y Watari, S Yanase, C Koizuka… - Nature plants, 2019 - nature.com … to cure mitochondrial diseases 7,8 . In these studies, disease-causi…

" CRISPR-Cas9 system: A new-fangled dawn in gene editing D Gupta, O Bhattacharjee, D Mandal, MK Sen, D Dey… - Life sciences, 2019 - Elsevier … an N terminal Mitochondrial targeting sequence (MTS) to direct its transport to the mitochondria…

" A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing BY Mok, MH de Moraes, J Zeng, DE Bosch, AV Kotrys… - Nature, 2020 - nature.com … double-strand breaks, a capability that has the potential to model mitoc…

" mt DNA heteroplasmy level and copy number indicate disease burden in m. 3243A> G mitochondrial disease JP Grady, SJ Pickett, YS Ng, CL Alston… - EMBO molecular …, 2018 - embopress.org … We thank the patients who participated in this stud…

" Drug development for the therapy of mitochondrial diseases V Weissig - Trends in molecular medicine, 2020 - Elsevier … TAK-831, an inhibitor of D-amino acid oxidase, is being tested as an intervention forFriedreich’s ataxia, a mitochondr…

" Emerging therapies for mitochondrial diseases M Hirano, V Emmanuele, CM Quinzii - Essays in biochemistry, 2018 - portlandpress.com … CoQ10 Children with mitochondrial diseases with mtDNA mutations or specific OXPHOScomplexes defects Phas…

" Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo PA Gammage, C Viscomi, ML Simard, ASH Costa… - Nature medicine, 2018 - nature.com … mitochondrial disease, bearing the point mutation m.5024C>T in … disease-rele…

" Mitochondrial diseases: the contribution of organelle stress responses to pathology A Suomalainen, BJ Battersby - Nature reviews Molecular cell biology, 2018 - nature.com … mitochondrial DNA (mtDNA) maintenance and mitochondrial translat…

" Mitochondrial medicine in the omics era J Rahman, S Rahman - The Lancet, 2018 - Elsevier … , and mitochondrial dynamics (table 1). Conversely, dozens of mitochondrial disease mutations… describing mitochondrial disease mutations (collate…

" Advancing genomic approaches to the molecular diagnosis of mitochondrial disease SL Stenton, H Prokisch - Essays in Biochemistry, 2018 - portlandpress.com … clinical presentation, are uncommon in mitochondrial disease making the selectio…

" [HTML] Advances in mt-tRNA mutation-caused mitochondrial disease modeling: patients' brain in a dish S Povea-Cabello, M Villanueva-Paz… - Frontiers in …, 2021 - frontiersin.org … , MELAS (mitochondrial encephalomyopathy, lactic acidosis,…

" Mutations in FASTKD2 are associated with mitochondrial disease with multi‐OXPHOS deficiency X Wei, M Du, D Li, S Wen, J Xie, Y Li, A Chen… - … Mutation, 2020 - Wiley Online Library … Alternatively, a patient with FASTKD2 mutation can sho…

" [HTML] Mitochondrial diseases: hope for the future OM Russell, GS Gorman, RN Lightowlers, DM Turnbull - Cell, 2020 - Elsevier … Several studies have shown that nuclear genetic defects are the main cause of childhoodmitochondrial disease …